e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Efficient synthesis of novel NK1 receptor antagonists: selective 1, 4-addition of grignard reagents to 6-chloronicotinic acid derivatives

F Hoffmann-Emery, H Hilpert, M Scalone…

Index: Journal of Organic Chemistry, , vol. 71, # 5 p. 2000 - 2008

Full Text: HTML

Citation Number: 29

Abstract

... The Journal of Organic Chemistry. ... 4070 Basel, Switzerland. J. Org. Chem. , 2006, 71 (5), pp 2000–2008. DOI: 10.1021/jo0523666. Publication Date (Web): February 9, 2006. Copyright © 2006 American Chemical Society. ...

6-(4-Methylpiperazin-1-yl)-4-(2-methylphenyl)nicotinamide Structure

6-(4-Methylpipe...

~%

Netupitant Structure

[6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester Structure

[6-(4-methyl-pi...

~%

Netupitant Structure

6-chloro-4-o-tolyl-nicotinamide Structure

6-chloro-4-o-to...

~%

Netupitant Structure

6-chloro-4-o-tolyl-nicotinic acid Structure

6-chloro-4-o-to...

~%

Netupitant Structure

N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide Structure

N-tert-butyl-6-...

~%

Netupitant Structure

3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- Structure

3-PYRIDINECARBO...

~%

Netupitant Structure

O-TOLYLMAGNESIUM CHLORIDE Structure

O-TOLYLMAGNESIU...

~%

Netupitant Structure

2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid Structure

2-[3,5-bis(trif...

~%

Netupitant Structure

3,5-Bis(trifluoromethyl)bromobenzene Structure

3,5-Bis(trifluo...

~%

Netupitant Structure

2-[3,5-bis-(Trifluoromethyl)phenyl]propan-2-ol Structure

2-[3,5-bis-(Tri...

~%

Netupitant Structure

6-Chloronicotinic acid Structure

6-Chloronicotin...

~%

6-Chloro-N-tert-butylnicotinamide Structure

6-Chloro-N-tert...

Design and synthesis of a novel, achiral class of highly pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365]

Design and synthesis of a novel, achiral class of highly pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365]

Design and synthesis of a novel, achiral class of highly pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365]

Design and synthesis of a novel, achiral class of highly pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365]

Design and synthesis of a novel, achiral class of highly pot...

[Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 5 p. 1362 - 1365]