Synthesis of Substituted Benzylamino??and Heterocyclylmethylamino Carbodithioate Derivatives of 4??(3H)??Quinazolinone and their Cytotoxic Activity

…, XL Zheng, YY Jiang, M Zhang, Y Wang…

Index: Cao, Sheng-Li; Feng, Yu-Ping; Zheng, Xiao-Lin; Jiang, Yu-Yang; Zhang, Mei; Wang, Yue; Xu, Meng Archiv der Pharmazie, 2006 , vol. 339, # 5 p. 250 - 254

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Citation Number: 26

Abstract

Abstract A new series of substituted benzylamino-and heterocyclylmethylamino carbodithioate derivatives of 4-(3H)-quinazolinone were synthesized via four steps starting from 2-amino-5-methylbenzoic acid and initially screened against A-549 (human non-small cell lung cancer), HCT-8 (human colon cancer), and Bel-7402 (human liver cancer) cell lines at the single concentration of 5 μg/mL using the colorimetric MTT assay. The IC 50 values ...