Abstract A convenient new route to 2-(F-alkyl)-4-hydroxyquinolines has been developed. In the presence of triethylamine, treatment of ethyl 2, 2-dihydropolyfluoroalkanoates with aromatic amines in acetonitrile at 70 C led to a mixture of the corresponding enamines and imines, which was cyclized in polyphosphoric acid (PPA) at 170 C to give 2-(F-alkyl)-4- hydroxyquinolines in good yield.
