Tetrahedron Letters

Synthesis of 5-substituted 3-mercapto-1, 2, 4-triazoles via Suzuki–Miyaura reaction

S Katkevica, P Salun, A Jirgensons

Index: Katkevica, Sarmite; Salun, Pavlo; Jirgensons, Aigars Tetrahedron Letters, 2013 , vol. 54, # 34 p. 4524 - 4525

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Citation Number: 4

Abstract

Abstract 3-Bromo-and 3-iodo-N, S-dibenzyl-5-mercapto-1, 2, 4-triazoles were prepared and demonstrated as versatile building blocks for Suzuki–Miyaura cross-coupling with aryl, heteroaryl, and vinyl boronic acid derivatives. Deprotection of the resulting coupling products provided 5-substituted-3-mercapto-1, 2, 4-triazoles in good overall yields. This represents a novel and convenient approach for the introduction of a 3-mercapto-1, 2, 4- ...