Syntheses of Apogalanthamine Analogs as α-Adrenergic Blocking Agents

…, H IKEDA, K KITAHIRO, H MATSUMOTO

Index: Kobayashi; Kihara; Shizu; Katayama; Ikeda; Kitahiro; Matsumoto Chemical and Pharmaceutical Bulletin, 1977 , vol. 25, # 12 p. 3312 - 3323

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Abstract

The apogalanthamine analogs, 10, 11-methylenedioxy-, 10, 11-dimethoxy-, and 11, 12- dimethoxy-5, 6, 7, 8-tetrahydrodibenz [c, e] azocines (2, 5, and 7, respectively) and their N- substituted derivatives (1, 3, 4, 6, 8, and 9) as α-adrenergic blocking agents, and the related compounds, 2, 3-dimethoxy-, 2, 3-methylenedioxy-, and 11-methoxy-5, 6, 7, 8- tetrahydrodibenz [c, e] azocines (10, 11, and 12, respectively) were synthesized by ...