e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1, 3, 8-triazaspiro [4.5] decan-4-one ring system

BJ Mavunkel, Z Lu, RR Goehring, S Lu…

Index: Journal of Medicinal Chemistry, , vol. 39, # 16 p. 3169 - 3173

Full Text: HTML

Citation Number: 20

Abstract

... Journal of Medicinal Chemistry. ... Scios Nova, Inc., 820 West Maude Avenue, Sunnyvale, California 94086. J. Med. Chem. , 1996, 39 (16), pp 3169–3173. DOI: 10.1021/jm950676i. Publication Date (Web): August 2, 1996. Copyright © 1996 American Chemical Society. ...

Structure

~%

4-Anilino-1-benzylpiperidine-4-carboxamide Structure

4-Anilino-1-ben...

N-Benzyl-4-piperidone Structure

N-Benzyl-4-pipe...

~%

4-Piperidinecarboxamide,4-[(4-methylphenyl)amino]-1-(phenylmethyl)- Structure

4-Piperidinecar...

p-Toluidine Structure

~%

4-Piperidinecarboxamide,4-[(4-methylphenyl)amino]-1-(phenylmethyl)- Structure

4-Piperidinecar...

4-Piperidinecarbonitrile,4-[(4-methylphenyl)amino]-1-(phenylmethyl)- Structure

4-Piperidinecar...

~%

4-Piperidinecarboxamide,4-[(4-methylphenyl)amino]-1-(phenylmethyl)- Structure

4-Piperidinecar...

N-Benzyl-4-piperidone Structure

N-Benzyl-4-pipe...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

4-Anilino-1-benzyl-4-piperidinecarbonitrile Structure

4-Anilino-1-ben...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

4-Anilino-1-benzylpiperidine-4-carboxamide Structure

4-Anilino-1-ben...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

Structure

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

1-(phenylmethyl)-4,4-(2-phenyl-2,4-diaza-4-oxo-cyclopentane)piperidine Structure

1-(phenylmethyl...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

tert-butyl 3-(2-methoxy-2-oxoethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate Structure

tert-butyl 3-(2...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

N/A Structure

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

1-phenyl-1,3,8-triazaspiro[4.5]dec-2-en-4-one Structure

1-phenyl-1,3,8-...

~%

2-(8-(TERT-BUTOXYCARBONYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-3-YL)ACETIC ACID Structure

2-(8-(TERT-BUTO...

Syntheses, biological evaluation, and molecular modeling of ...

[Journal of Medicinal Chemistry, , vol. 48, # 24 p. 7720 - 7732]