Rapid formation of diphenylmethyl ethers and thioethers using microwave irradiation and protic ionic liquids

…, MD Johnstone, CL Fleming, FM Pfeffer, SM Hickey…

Index: Altimari, Jarrad M.; Delaney, Joshua P.; Servinis, Linden; Squire, Jennifer S.; Thornton, Megan T.; Khosa, Simren K.; Long, Benjamin M.; Johnstone, Mark D.; Fleming, Cassandra L.; Pfeffer, Frederick M.; Hickey, Shane M.; Wride, Matthew P.; Ashton, Trent D.; Fox, Bronwyn L.; Byrne, Nolene; Henderson, Luke C. Tetrahedron Letters, 2012 , vol. 53, # 16 p. 2035 - 2039

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Citation Number: 15

Abstract

Using microwave irradiation and protic ionic liquids (pIL) as co-solvent and catalyst for the synthesis of several diphenylmethyl ethers was achieved. The desired ethers were isolated simply by filtration through a silica plug to remove the pIL and proceeded in high yields (60– 98%). These reactions were extremely rapid (10–30min) and occurred under mild conditions (80° C). This protocol was also successfully applied to the synthesis of thioethers.