Halogenated secondary metabolites are ubiquitous in Nature. Over 3000 natural products containing chlorine, bromine, or iodine have been characterized to date, and scores are added to the list each year. 1 There is, however, a notable scarcity of fluorinated natural products, of which only 13 are known. 2 This may in part stem from the limited bioavailability of fluoride, which exists primarily in insoluble mineral forms. 3, 4 Equally elusive is an ...
