Martinellic acid (1a) and martinelline (1b) were isolated by Witherup, Varga and co-workers at Merck Research Laboratories from the roots of the tropical plant Martinella iquitosensis. 1 These alkaloids are the first naturally occurring nonpeptide bradykinin B 1 and B 2 receptor antagonists. The novel tricyclic pyrrolo[3,2-c]quinoline core has been the object of intense synthetic effort. 2 We have developed an eight-step synthesis of the model triamine 2, which ...
