Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity.

…, T Kamei, M Shibata, T Tatsuoka, M Yoshida…

Index: Mizuno, Akira; Inomata, Norio; Miya, Mikiko; Kamei, Tomoe; Shibata, Makoto; Tatsuoka, Toshio; Yoshida, Maki; Takiguchi, Chikako; Miyazaki, Tomoko Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 2 p. 246 - 256

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Citation Number: 10

Abstract

A series of 1-aminoalkyl-pyrrolo [2, 3-c] azepin-8-one derivatives was synthesized and evaluated as α 1 adrenergic and serotonin 2 (5-HT 2) receptor antagonists, with the aim of finding a novel antihypertensive agent potently exhibiting both activities. Some compounds with a 4-[4-(4-fluorobenzoyl) piperidino] butyl group at the 1-position exhibited both activities, and varied significantly in terms of the substituents at the 4-position of the ...