Development of step-specific PET tracers for studying fatty acid β-oxidation: biodistribution of [1-11 C] octanoate analogs in rats and a cat

H Kawashima, Y Kuge, K Yajima, Y Miyake…

Index: Kawashima, Hidefumi; Yajima, Kazuyoshi; Kuge, Yuji; Hashimoto, Naoto; Miyake, Yoshihiro Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 3 p. 181 - 193

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Citation Number: 9

Abstract

To evaluate the potential of [1-11C]-3-(R, S)-methyloctanoate (BMOA),[1-11C]-2-octynoate, and [1-11C]-2-decynoate as PET tracers for studying particular steps in fatty acid β- oxidation, we examined the pharmacokinetics of these compounds in rats and a cat. In rats given these compounds, high levels of radioactivity accumulated in the heart, liver, and kidneys, suggesting their potential as tracers for studying β-oxidation in these tissues. ...