Isocytosine H 2-receptor histamine antagonists II. Synthesis and evaluation of biological activity at histamine H 1-and H 2-receptors of 5-(heterocyclyl) …

TH Brown, RC Blakemore, P Blurton, GJ Durant…

Index: Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al. European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72

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Citation Number: 14

Abstract

Abstract A series of 2-[2-(5-methyl-4-imidazolylmethylthio) ethylamino]-4-pyrimidones was synthesised based on oxmetidine 2, in which the methylenedioxyphenyl group of 2 was replaced by a heterocyclic ring. Good H 2-receptor antagonist activity was retained over a range of basic and neutral heterocyclic substituents. Replacement of the 5-methyl-4- imidazolyl ring in selected compounds with 2-thiazolyl and, particularly, 3-bromo-2-pyridyl ...

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