Tetrahedron

Synthesis and evaluation of fully (5-amidoisophthalic acid)-functionalised polyacrylamides as selective inhibitors of the beta crystal polymorph of l-glutamic acid

DM Kelly, HA Moynihan

Index: Kelly, Dawn M.; Moynihan, Humphrey A. Tetrahedron, 2010 , vol. 66, # 29 p. 5459 - 5466

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Citation Number: 4

Abstract

Poly-N-5-acrylamidoisophthalic acid (4), poly-N-(5-(N′-(3, 5-dicarboxyphenyl) carbamoyl) pentyl) acrylamide (10a) and poly-N-(11-(N′-(3, 5-dicarboxyphenyl) carbamoyl) undecyl) acrylamide (10b) were prepared and assessed as polymorph-selective crystallization inhibitors of the stable β form of l-glutamic acid. Polymerization was carried out as the final step in the preparation of 10a and 10b to ensure the preparation of fully functionalized ...