SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl) piperazine-2-carboxamides: Potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C …

RG Gentles, M Ding, X Zheng, L Chupak…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3142 - 3147

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Citation Number: 3

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... HCV; NS5B; Allosteric inhibitors; SAR. Hepatitis C virus (HCV) infection is a pressing medical problem: 4 million cases have been reported in the United States and approximately 180 million people are infected globally. ...