Solution and solid-Phase synthesis of potent inhibitors of hepatitis C Virus NS3 proteinase

…, S Jordan, PB Kay, RC Lazell, TM Raynham

Index: Beevers, Rebekah; Carr, Maria G; Jones, Philip S; Jordan, Steven; Kay, Paul B; Lazell, Robert C; Raynham, Tony M Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 4 p. 641 - 643

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Citation Number: 30

Abstract

A versatile route for the synthesis of homochiral α-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution or solid-phase chemistry resulted in potent inhibitors of the Hepatitis C Virus NS3 proteinase. ... A versatile route for the synthesis of homochiral α-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution ...