Synthetic polyamine analogs as antineoplastics

…, JS McManis, TR Hawthorne, JRT Vinson…

Index: Bergeron, Raymond J.; Neims, Allen H.; McManis, James S.; Hawthorne, Thomas R.; Vinson, John R. T.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1183 - 1190

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Citation Number: 188

Abstract

In this paper, we report on the synthesis and biological activity of a number of N-alkylated spermine compounds. The dialkylspermines N1, N12-dimethylspermine (DMSPM-P), N', N12-diethylspermine (DESPM-3), and N', N12-dipropylspermine (DPSPM-4) are all shown to inhibit the growth of L1210 cells in culture with IC50 values of less than 1 pM at 96 h. Furthermore, DESPM-3 is shown to be similarly active against Daudi and HL-60 cells in ...