(Dimethoxy??and Dihalopyridyl) boronic Acids and Highly Functionalized Heteroarylpyridines by Suzuki Cross??Coupling Reactions

AE Smith, KM Clapham, AS Batsanov…

Index: Smith, Amy E.; Clapham, Kate M.; Batsanov, Andrei S.; Bryce, Martin R.; Tarbit, Brian European Journal of Organic Chemistry, 2008 , # 8 p. 1458 - 1463

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Citation Number: 10

Abstract

Abstract We report the synthesis of (2, 6-dimethoxy-3-pyridyl) boronic acid (2),(2, 3- dimethoxy-4-pyridyl) boronic acid (4),(2, 6-difluoro-3-pyridyl) boronic acid (6),(2, 6-dichloro-3- pyridyl) boronic acid (8) and (2, 3-dichloro-4-pyridyl) boronic acid (10) by directed ortho- metalation reactions on the corresponding disubstituted pyridine precursor, followed by the reaction with triisopropyl borate (TPB) or trimethyl borate. Thereactivity of the ...