6-Hydroxy-1, 2, 3, 4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides

E Sperlinga, P Kosson, Z Urbanczyk-Lipkowska…

Index: Sperlinga, Emanuela; Kosson, Piotr; Urbanczyk-Lipkowska, Zofia; Ronsisvalle, Giuseppe; Carr, Daniel B.; Lipkowski, Andrzej W. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2467 - 2469

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Citation Number: 14

Abstract

6-Hydroxy-1, 2, 3, 4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand–receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with d, l-6Htc prove initial prediction.