Tetrahedron

Synthesis and characterisation of severely hindered P-OR compounds

DBG Williams, TE Netshiozwi

Index: Williams, D. Bradley G.; Netshiozwi, Takelani E. Tetrahedron, 2009 , vol. 65, # 48 p. 9973 - 9982

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Citation Number: 7

Abstract

P-Cl substrates were converted into their P-OR analogues from hindered alcohols using an amine base. Where the system was severely hindered, more forcing conditions were required that necessitated the presence of a metal alkoxide nucleophile before successful reactions were observed. In some instances, the products were thermally unstable and reverted to alkenes by elimination reactions, while others were sensitive to moisture. Here, ...