The 6-propyl homolog of aspergillic acid was synthesized. N-Leucyl-0-benzylhydroxylamine, prepared by reaction of phthalylleucyl chloride with 0-benzylhydroxylamine, followed by treatment with hydrazine hydrate, was treated with 1-chloro-2-pentanone oxime; the product was hydrolyzed to give N-[4-methyl-2-(2-oxopentyl-amino) valeryl]-0-benzylhydroxylamine, which was catalytically hydrogenated to give the corresponding hydroxamic acid. The ...
