Synthesis of 9-(2-phosphonylmethoxyethyl) adenine and related compounds

A Holý, I Rosenberg

Index: Holy, Antonin; Rosenberg, Ivan Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 11 p. 2801 - 2809

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Citation Number: 183

Abstract

Abstract Diethyl 2-hydroxyethoxymethanephosphonate (VIII) was converted into diethyl 2- halogenoethoxymethanephosphonates IXa and IXb by reaction with triphenylphosphine and tetrachloromethane or tetrabromomethane; analogous reaction of VIII with p-toluenesulfonyl chloride afforded diethyl 2-(p-toluenesulfonyloxy) ethoxymethanephosphonate (IXc). Reaction of sodium salt of adenine with compounds IX led to 9-(2- ...