Quinoxalin-2-carboxamides: synthesis and pharmacological evaluation as serotonin type-3 (5-HT3) receptor antagonists

R Mahesh, T Devadoss, DK Pandey…

Index: Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Yadav, Shushil Kumar Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 5 p. 610 - 615

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Citation Number: 8

Abstract

A series of quinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT3 receptor antagonists and synthesized by condensing the carboxylic group of quinoxalin-2-carboxylic acid with various amines in the presence of 1-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1-hydroxybenzotriazole. The structures of the synthesized compounds were confirmed by physical and spectroscopic ...

~50%

Biocatalytic oxidation of 2-methylquinoxaline to 2-quinoxali...

[Wong, John W.; Watson Jr., Harry A.; Bouressa, James F.; Burns, Michael P.; Cawley, James J.; Doro, Albert E.; Guzek, Donald B.; Hintz, Michael A.; McCormick, Ellen L.; Scully, Douglas A.; Siderewicz, Joseph M.; Taylor, William J.; Truesdell, Susan J.; Wax, Richard G. Organic Process Research and Development, 2002 , vol. 6, # 4 p. 477 - 481]

Design, synthesis and structure–activity relationship of nov...

[Mahesh, Radhakrishnan; Devadoss, Thangaraj; Pandey, Dilip Kumar; Bhatt, Shvetank; Yadav, Shushil Kumar Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6773 - 6776]

Quinoxalin-2-carboxamides: synthesis and pharmacological eva...

[Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 5 p. 610 - 615]

An efficient synthesis of 2-quinoxalinecarboxylic acid

[Organic Process Research and Development, , vol. 8, # 4 p. 666 - 669]