Abstract 2, 4-Dimethoxy-and 2, 4-dibenzyloxy-5-lithiopyrimidines, obtained from the corresponding substituted 5-bromopyrimidines, react with trimethylsilyl chloride or trimethylstannyl chloride to give the appropriate 5-trimethylsilyl or 5-trimethylstannyl derivatives. The following compounds were synthesized by this reaction sequence: 2, 4- dimethoxy-5-trimethylsilylpyrimidine (2), 2, 4-dibenzyloxy-5-trimethylsilylpyrimidine (3), 2, ...
