Rhodium-catalysed addition of organotrialkoxysilanes to α-substituted acrylic esters

JD Hargrave, J Herbert, G Bish, CG Frost

Index: Hargrave, Jonathan D.; Herbert, Jennifer; Bish, Gerwyn; Frost, Christopher G. Organic and Biomolecular Chemistry, 2006 , vol. 4, # 17 p. 3235 - 3241

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Citation Number: 29

Abstract

The cationic rhodium complex [Rh (cod) 2][BF4] effectively catalyses the 1, 4-addition of organotrialkoxysilanes to α-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and α-amino acid derivatives.