Palladium??Catalyzed Carbonylative Synthesis of Quinazolinones from 2??Aminobenzamide and Aryl Bromides

…, L He, H Neumann, M Beller

Index: Wu, Xiao-Feng; He, Lin; Neumann, Helfried; Beller, Matthias Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12635 - 12638

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Abstract

2-Aryl quinazolin-4 (3H)-one (quinazolinone) is a naturally occurring class of heterocycles which can exhibit a wide range of biological activities (Scheme1). Their reported properties included anticancer, antiviral, anti-inflammatory, anti-microbial activity among others [1] Additionally, quinazolinones are used as ligands for benzodiazepine and AMPA receptors in the CNS system or as DNA binders.[2] Because of their importance, many useful synthetic ...