Synthesis, resolution, and absolute configuration of novel tricyclic benzodiazepines

JM Matthews, AB Dyatkin, M Evangelisto…

Index: Matthews, Jay M.; Dyatkin, Alexey B.; Evangelisto, Mary; Gauthier, Diane A.; Hecker, Leonard R.; Hoekstra, William J.; Liu, Fuqiang; Poulter, Brenda L.; Sorgi, Kirk L.; Maryanoff, Bruce E. Tetrahedron Asymmetry, 2004 , vol. 15, # 8 p. 1259 - 1267

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Citation Number: 29

Abstract

The synthesis, resolution, and stereochemical characterization of novel piperazino-, thiazino- , and oxazinobenzodiazepines are described. The absolute stereochemistry of the heterotricycles was determined by using X-ray crystallography and the enantiomeric purity was determined by using Pirkle-solvent NMR techniques and chiral HPLC.