A variety of novel 2, 4-diarylthiazole-5-acetic acids and related compounds was prepared by the Hantzsch thiazole synthesis and evaluated as antiinflammatory agents on the carrageenin-induced edema assay in the rat. Two compounds, namely 4-(4-chlorophenyl)-2- phenylthiazole-5-acetic acid (24) and 4-(4-chlorophenyl)-2-(3-methylphenyl)-thiazole-5- acetic acid (31), were found to possess activity comparable with indomethacin. Derivatives ...
