Synthesis of 2trans??alkene??mono??and??poly??ynoic acids with a triple bond in the 5??position and their hydrogenation. A new synthesis of arachidonic acid

L Heslinga, HJJ Pabon…

Index: Heslinga,L. et al. Recueil des Travaux Chimiques des Pays-Bas, 1973 , vol. 92, p. 287 - 303

Full Text: HTML

Citation Number: 20

Abstract

Abstract 27Trans-alkenoic, 2trans-alkenemonoynoic and 2trans-alkenepolyynoic acids with the first triple bond in the 5-position could be obtained in high yield by coupling 1-alkyl-and 1- mono-or-poly-ynylmagnesium bromides with 4-bromocrotonic acid in tetrahydrofuran at low temperature.