e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1, 2-benzisoxazoles

JT Strupczewski, RC Allen, BA Gardner…

Index: Journal of Medicinal Chemistry, , vol. 28, # 6 p. 761 - 769

Full Text: HTML

Citation Number: 89

Abstract

... J. Med. Chem. 1982, 25, 36. 0 1985 American Chemical Society Page 2. 762 Journal of Medicinal Chemistry, 1985, Vol. 28, No. 6 Table I. 4-Benzoylpiperidines Strupczewski et al. yield," recrystC no. R X Y method % mp,b OC solvent formula anal.d C, H, N, F ...

6-fluoro-3-(1-formyl-4-piperidinyl)-1,2-benzisoxazole Structure

6-fluoro-3-(1-f...

~%

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Structure

6-Fluoro-3-(4-p...

1-formyl-4-(2,4-difluorobenzoyl)piperidine oxime Structure

1-formyl-4-(2,4...

~%

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Structure

6-Fluoro-3-(4-p...

3-(4-Piperidinyl)-1,2-benzisoxazole N-Carbamic Acid Phenyl Ester Structure

3-(4-Piperidiny...

~%

3-Piperidin-4-yl-benzo[d]isoxazole Structure

3-Piperidin-4-y...

4-Chloro-1-methylpiperidine Structure

4-Chloro-1-meth...

~%

3-Piperidin-4-yl-benzo[d]isoxazole Structure

3-Piperidin-4-y...

(2-fluorophenyl)-(1-methylpiperidin-4-yl)methanone Structure

(2-fluorophenyl...

~%

3-Piperidin-4-yl-benzo[d]isoxazole Structure

3-Piperidin-4-y...

2-Fluorobenzonitrile Structure

2-Fluorobenzonitrile

~%

3-Piperidin-4-yl-benzo[d]isoxazole Structure

3-Piperidin-4-y...

3-(1-methyl-4-piperidinyl)-1,2-benzisoxazole Structure

3-(1-methyl-4-p...

~%

3-Piperidin-4-yl-benzo[d]isoxazole Structure

3-Piperidin-4-y...

(E)-1-Acetyl-α-(5-fluoro-2-hydroxyphenyl)-N-hydroxy-4-piperidinemethanimine Structure

(E)-1-Acetyl-α-...

~%

5-Fluoro-3-piperidin-4-yl-benzo[d]isoxazole Structure

5-Fluoro-3-pipe...

(E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine Structure

(E)-1-Acetyl-N-...

~%

5-Fluoro-3-piperidin-4-yl-benzo[d]isoxazole Structure

5-Fluoro-3-pipe...

3-(1-Acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole Structure

3-(1-Acetyl-4-p...

~%

5-Fluoro-3-piperidin-4-yl-benzo[d]isoxazole Structure

5-Fluoro-3-pipe...

(E)-2-(5-Methoxy)phenol 4-(N-Benzyloxycarbonyl)piperidinyl-methanone O-Acetyl Oxime Structure

(E)-2-(5-Methox...

~%

6-Methoxy-3-[4-(N-benzyloxycarbonyl)piperidinyl]-1,2-benzisoxazole Structure

6-Methoxy-3-[4-...

(E)-2-(5-Methoxy)phenol 4-(N-Benzyloxycarbonyl)piperidinyl-methanone Oxime Structure

(E)-2-(5-Methox...

~%

6-Methoxy-3-[4-(N-benzyloxycarbonyl)piperidinyl]-1,2-benzisoxazole Structure

6-Methoxy-3-[4-...

Process improvements for the preparation of kilo quantities ...

[Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532]

Process improvements for the preparation of kilo quantities ...

[Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532]

Process improvements for the preparation of kilo quantities ...

[Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532]

Process improvements for the preparation of kilo quantities ...

[Organic Process Research and Development, , vol. 7, # 4 p. 521 - 532]