For further investigation into both bioactivity and synthetic methodology, our group has developed a novel and practical synthetic approach for 1,6-dideoxynojirimycin from relatively inexpensive and accessible l-sorbose. With the fixed chiral centers of the starting material and the almost quantitative stereoselectivity in the reductive amination step, 6a the enantiochemistry of this approach is fully guaranteed. ... The amine 5 was adsorbed onto Dowex 50 (H + ) resin, and the ...
