Tetrahedron

Synthesis of 4, 5-diaminopyrrolo [1, 2-a] quinoline derivatives by annulation of N, N-dialkyl [2-(pyrrol-1-yl) benzylidene] ammonium salts in the presence of an …

…, A Takanohashi, K Hashimoto, O Morikawa, H Konishi

Index: Kobayashi, Kazuhiro; Takanohashi, Atsushi; Hashimoto, Kenichi; Morikawa, Osamu; Konishi, Hisatoshi Tetrahedron, 2006 , vol. 62, # 13 p. 3158 - 3161

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Citation Number: 10

Abstract

A facile synthetic method for 4, 5-diaminopyrrolo [1, 2-a] quinoline derivatives has been developed. Treatment of 2-(pyrrol-1-yl) benzaldehydes with secondary amine hydrochloride/NaI/TMSCl/Et3N in the presence of an isocyano compound leads to the formation of 4-alkyl (or aryl) amino-5-dialkylaminopyrrolo [1, 2-a] quinolines.