Tetrahedron: Asymmetry

Synthesis of enantiomerically enriched α, α-disubstituted β, γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo (III)

I Viera, E Manta, L González, G Mahler

Index: Viera, Ignacio; Manta, Eduardo; Gonzalez, Lucia; Mahler, Graciela Tetrahedron Asymmetry, 2010 , vol. 21, # 5 p. 631 - 635

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Citation Number: 7

Abstract

Novel α, α-disubstituted epoxy esters were prepared in enantiopure form by hydrolytic kinetic resolution (HKR) of the corresponding racemic mixtures using chiral salenCo (III) as catalyst. The methodology provides a convenient route to enantioenriched β, γ-epoxy esters 2a, 2c and 2d.