Synthesis of tricyclic-2-aminoindoles by intramolecular 1, 3-dipolar cycloaddition of 1-ω-azidoalkylindoles

…, E Cuevas, JM Muchowski, R Cruz-Almanza

Index: De la Mora, Marco A.; Cuevas, Erick; Muchowski, Joseph M.; Cruz-Almanza, Raymundo Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5351 - 5353

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Citation Number: 12

Abstract

2-Aminoindoles in which the nitrogen atoms are connected by a polymethylene chain 1 are a relatively rare class of compounds, some of which have recently been patented as 5HT4-receptor antagonists. 1 The pyrimidino[1,2-a]indole derivatives (1, n=2) are most expeditiously synthesized by the remarkable phosphorous oxychloride induced rearrangement of 1-phenyl-2-acylpyrazolidines (Golubeva synthesis). 2., , and They can also be prepared from m-dinitrobenzene ...