The Journal of organic chemistry

Trifluoromethylation of Alkenyl Bromides and Iodides (Including 5-Iodouracils) with (CF3) 2Hgand Cu (“Trifluoromethylcopper”) 1

I Nowak, MJ Robins

Index: Nowak, Ireneusz; Robins, Morris J. Journal of Organic Chemistry, 2007 , vol. 72, # 7 p. 2678 - 2681

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Citation Number: 41

Abstract

Bromo-and iodoalkenes undergo trifluoromethylation efficiently in DMA with “CF3Cu” generated from (CF3) 2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen,-alkyl, or-alkenyl groups give products with stereochemical retention.