Tetrahedron: Asymmetry

A convenient enantioselective synthesis of trans-2-aryloxycyclohexan-1-ols using pig liver acetone powder (PLAP) as biocatalyst

D Basavaiah, PR Krishna, TK Bharathi

Index: Basavaiah, Deevi; Krishna, Peddinti Rama; Bharathi, Tirumala K. Tetrahedron: Asymmetry, 1995 , vol. 6, # 2 p. 439 - 454

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Citation Number: 13

Abstract

Pig liver acetone powder (PLAP) has been used as a biocatalyst for enantioselective hydrolysis of racemic trans-1-acetoxy-2-aryloxycyclohexannes to produce the resulting (R, R)-2-aryloxycyclohexan-1-ols upto> 99% enantiomeric purities.(R, R)-Selectivity in this hydrolysis of racemic trans-2-aryloxycyclohexyl acetates was explained on the basis of Jones' three dimensional active site-model.