Synthesis

A practical method for the preparation of nitriles from primary amides under non-acidic conditions

DS Bose, B Jayalakshmi

Index: Bose, D. Subhas; Jayalakshmi, B. Synthesis, 1999 , # 1 p. 64 - 65

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Citation Number: 14

Abstract

Abstract: In order to establish a mild conversion method of primary amides to nitriles, various types of carboxamides were treated with trifluoromethanesulfonic anhydride and triethylamine, as a dehydrating agent to obtain the desired nitriles in 84œ95% yields. Key words: trifluoromethanesulfonic anhydride, carboxamides, dehydration

~91%

~94%

~93%

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