Preparation of 1'-C Deuterated Synthons for RNA Synthesis by H-Phosphonate Method Aiming at Two-Dimensional NMR Secondary Structure Studies

…, D Šaman, M Vogtherr, S Limmer

Index: Arnold, Lubos; Pressova, Martina; Saman, David; Vogtherr, Martin; Limmer, Stefan Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, # 3 p. 389 - 403

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Citation Number: 9

Abstract

Abstract 1'-C Deuterated H-phosphonate synthons were prepared via a 12-step procedure starting from [1'-2 H] ribose. The procedure included nucleosidation of 1'-O-acetyl-2', 3', 5'-O- tribenzoyl [1'-2 H] ribose with appropriately protected nucleobases and preparation of nucleoside-H-phosphonates by slightly modified described procedures. The automated RNA synthesis of 5'-G* C* U* A* U* UUAU-3'and 3'-AC* G* A* U* A* AAGU-5'was ...