Antibacterially active substituted anilides of carboxylic and sulfonic acids

WM Linfield, TJ Micich, TJ Montville…

Index: Linfield, Warner M.; Micich, Thomas J.; Montville, Thomas J.; Simon, John R.; Murray, Ermellina B.; Bistline, Raymond G. Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1741 - 1746

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Citation Number: 9

Abstract

Anilides of carboxylic and sulfonic acids were prepared and tested for antimicrobial activity. While these anilides were ineffective against Gram-negative organisms, there was a good correlation between chemical structure and biological activity against Gram-positive species. Both the nature and position of the benzene ring substituents and the length of the carbon side chain affected the activity and specificity of the compounds. The highest activity was ...