Tetrahedron

Synthesis of new chiral 2-functionalized-1, 2, 3, 4-tetrahydroquinoline derivatives via asymmetric hydrogenation of substituted quinolines

AM Maj, I Suisse, C Hardouin, F Agbossou-Niedercorn

Index: Maj, Anna M.; Suisse, Isabelle; Hardouin, Christophe; Agbossou-Niedercorn, Francine Tetrahedron, 2013 , vol. 69, # 44 p. 9322 - 9328

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Citation Number: 7

Abstract

Abstract The asymmetric hydrogenation of a series of quinolines substituted by a variety of functionalized groups linked to the C2 carbon atom is providing access to optically enriched 2-functionalized 1, 2, 3, 4-tetrahydroquinolines in the presence of in situ generated catalysts from [Ir (cod) Cl] 2, a bisphosphine, and iodine. The enantioselectivity levels were as high as 96% ee.