Continuous flow-processing of organometallic reagents using an advanced peristaltic pumping system and the telescoped flow synthesis of (E/Z)-tamoxifen

…, JC Pastre, C Butters, D Guthrie, SV Ley

Index: Murray, Philip R. D.; Browne, Duncan L.; Pastre, Julio C.; Butters, Chris; Guthrie, Duncan; Ley, Steven V. Organic Process Research and Development, 2013 , vol. 17, # 9 p. 1192 - 1208

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Citation Number: 42

Abstract

A new enabling technology for the pumping of organometallic reagents such as n- butyllithium, Grignard reagents, and DIBAL-H is reported, which utilises a newly developed, chemically resistant, peristaltic pumping system. Several representative examples of its use in common transformations using these reagents, including metal–halogen exchange, addition, addition–elimination, conjugate addition, and partial reduction, are reported ...