Reaction Mechanism for the LiCl??Mediated Directed Zinc Insertion: A Computational and Experimental Study

…, A Muranaka, K Morokuma, M Uchiyama

Index: Liu, Ching-Yuan; Wang, Xuan; Furuyama, Taniyuki; Yasuike, Shuji; Muranaka, Atsuya; Morokuma, Keiji; Uchiyama, Masanobu Chemistry - A European Journal, 2010 , vol. 16, # 6 p. 1780 - 1784

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Abstract

In situ generation of organozinc reagents and their integration into CÀC bond-forming processes are of continuing interest because of the characteristically high chemo-and stereoselectivity.[1] In 2006, Knochel and co-workers discovered that the oxidative insertion of zinc dust into aryl halides is drastically accelerated in the presence of LiCl, thereby opening up a practical and efficient preparation method for aryl-and alkylzinc reagents.[2] ...