Norrisolide: Total synthesis and related studies

…, K Wen, C Kim, EA Theodorakis

Index: Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A. Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190

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Citation Number: 40

Abstract

Abstract A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused γ-lactone–γ-lactol ring system attached to a bicyclic hydrophobic core. Our studies led to the development of a expedient synthesis of such γ-lactone–γ-lactol motifs based on ring expansion of a fused cyclopropyl ester. Highlights of the synthetic strategy ...