Synthesis and serotonin receptor affinities of a series of enantiomers of. alpha.-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5- …

…, DH Lloyd, MP Johnson, AJ Hoffman

Index: Nichols; Lloyd; Johnson; Hoffman Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1406 - 1412

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Citation Number: 25

Abstract

A procedure for the preparation of optically pure a-methyltryptamines (AMTs) from substituted indoles was developed. The key step in the sequence was the reductive amination of substituted indole-2-propanones with the commercially available pure enantiomers of a-methylbenzylamine, followed by the chromatographic separation of the resulting pair of diastereomeric amines by preparative centrifugal (Chromatotron) ...