Tetrahedron letters

Efficient and simple synthesis of 3-aryl-1H-pyrazoles

AL Gérard, A Bouillon, C Mahatsekake, V Collot…

Index: Gerard, Anne-Laure; Bouillon, Alexandre; Mahatsekake, Clement; Collot, Valerie; Rault, Sylvain Tetrahedron Letters, 2006 , vol. 47, # 27 p. 4665 - 4669

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Citation Number: 36

Abstract

With the aim of constituting a library of pyrazoles linked to various scaffolds, we needed to develop efficient methodologies of cross-coupling reactions. These reactions were already achieved with halopyrazoles 5a and more recently with pyrazole nonaflates 5b and triflates 5c but very few references described the cross-coupling reaction of pyrazolyl boronic derivatives. In our knowledge, only Young et al. described the synthesis of 1H-pyrazol-3-yl-boronic acid and ...