The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo [3, 4-d] pyrimidine and 7-amino-2-benzyl-2H-pyrazolo [4, 3-d] pyrimidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays.
