Medicinal Chemistry Research

Docking, synthesis, and pharmacological investigation of novel substituted thiazole derivatives as non-carboxylic, anti-inflammatory, and analgesic agents

SN Thore, SV Gupta, KG Baheti

Index: Thore; Gupta, Sunil V.; Baheti, Kamalkishor G. Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3802 - 3811

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Citation Number: 10

Abstract

Abstract A series of substituted thiazole derivatives (6–16) were synthesized to obtain new compounds with potential anti-inflammatory and analgesic activities. At equimolar oral doses, compounds 3-(piperidin-1-yl-methyl)-1, 3, 4-oxadiazol-2-thione (14), 5-amino-4-ethyl ester pyrazole (15), and 5-amino-3-phenylpyrazole derivatives (16) displayed anti- inflammatory and analgesic activities significant to those of diclofenac sodium in the ...