Abstract 0 We report on the synthesis of N1-phenylquinolones in which the difluoromethoxy rnoiety is utilized as a halogen replacement. The antibacterlial activity is discussed with reference to Nl- halophenylquinolones. _ _ ~ _ _ ... In a previous communication,l we reported the use of the difluoromethoxy moiety as a potential replacement for the halogen in the 6-position of' the third generation quinolone- 3-carboxylic acids. In that study, we attribute the lack of ...
