e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
A Novel Solution??and Solid??Phase Approach to 2, 4, 5??tri??and 2, 4, 5, 6??tetrasubstituted pyrimidines and their conversion into condensed heterocycles
Abstract A novel general synthesis of 2, 4, 5-tri-and 2, 4, 5, 6-tetrasubstituted pyrimidines 5a– d and 7a, e, f, g by condensation of thiouronium salts of type 3 with (ethoxymethylidene) malononitrile (4) and [bis (methylthio) methylidene] malononitrile (6), respectively, was first established in solution (Scheme 1) and successfully transferred onto solid support by using the polymer-bound thiouronium salt 11 (Scheme 3). Further investigations were directed ...
