Tetrahedron

The Ugi reaction with CF 3-carbonyl compounds: effective synthesis of α-trifluoromethyl amino acid derivatives

…, NE Shevchenko, ES Balenkova, GV Roeschenthaler…

Index: Gulevich, Anton V.; Shevchenko, Nikolay E.; Balenkova, Elisabeth S.; Roeschenthaler, Gerd-Volker; Nenajdenko, Valentine G. Tetrahedron, 2008 , vol. 64, # 51 p. 11706 - 11712

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Citation Number: 47

Abstract

The Ugi reaction with CF3-carbonyl compounds is described in detail. The method is efficient for the multicomponent preparation of α-trifluoromethyl (Tfm) amino acids, α-Tfm containing dipeptides, and iminodicarboxylic acids. In addition, the first protected CF3-opine derivative was prepared. The scope, limitations, and stereochemistry of the approach are discussed.