Phosphonates and their derivatives are important analogs of nucleic acids, l peptides, 2 lipids: other biologically important phosphates: and as haptens for preparation of catalytic antib~ dies.~ Currently, phosphonate esters (1, X= 0, Y= 0, Z= 0) and phosphonamidates (1, X= NR, Y= 0, Z= 0) are generally formed by first activating a phosphonate monoester to the phosphonochloridate with thionyl chloride2 or oxalyl chloride: followed by coupling of the ...
